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86 Notch signaling pathway Notch signaling, intimately involved in embryonic development and maintenance of multicellular organisms in adults, is activated by ligand-receptor interaction between adjacent cells, which leads to successive proteolytic cleavages and releases the notch intracellular domain (NICD)
A key driver to promote HCC: Cellular crosstalk in tumor microenvironment
Yet, we administer sertraline only once every 3 days to reach a peak dosage, while patients have a daily oral intake with a maximum of 250 mg
& Yang, J
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